| Ache |
Family Time |
24 Oct 2022 |
| French bread |
The Guardian Quick |
19 Oct 2022 |
| Nociceptor’s detection |
Wall Street Journal |
13 Oct 2022 |
| Ache |
USA Today |
10 Oct 2022 |
| A backache is one |
Family Time |
12 Sep 2022 |
| What some say is necessary for gain |
Universal |
06 Sep 2022 |
| Nuisance |
LA Times Daily |
26 Aug 2022 |
| Hurt |
The Telegraph Quick |
18 Aug 2022 |
| Hurt; anguish |
The Telegraph Quick |
08 Aug 2022 |
| Ache |
Eugene Sheffer |
15 Jul 2022 |
| Total hassle |
USA Today |
01 Jul 2022 |
| Hassle |
New York Times |
16 Jun 2022 |
| Annoyance |
Universal |
07 Jun 2022 |
| Bodily suffering |
The Times Concise |
18 May 2022 |
| Wince cause, maybe |
Wall Street Journal |
07 May 2022 |
| The distress of hen parties without Esther |
Irish Times Crosaire |
29 Apr 2022 |
| Aspirin target |
Newsday |
03 Apr 2022 |
| Aspirin target |
Thomas Joseph |
29 Mar 2022 |
| Real hassle |
The Washington Post |
14 Mar 2022 |
| Real hassle |
LA Times Daily |
14 Mar 2022 |
| A symptom of physical hurt or emotional distress |
Irish Times Simplex |
19 Feb 2022 |
| Reason for using a heating pad |
USA Today |
10 Jan 2022 |
| Bother |
New York Times |
22 Dec 2021 |
| Discomfort cause |
LA Times Daily |
24 Nov 2021 |
| Reason to keep rubbing one's back |
Family Time |
21 Nov 2021 |
| Distress |
Canadiana |
01 Nov 2021 |
| Royal ___ |
New York Times |
16 Oct 2021 |
| Affliction I found aboard vessel |
The Times Cryptic |
14 Oct 2021 |
| Bodily suffering |
The Times Concise |
17 Sep 2021 |
| Distress |
Wall Street Journal |
20 Jul 2021 |
| Grimace inducer |
Wall Street Journal |
07 Jul 2021 |
| Reason for applying a medicated plaster |
USA Today |
07 Jul 2021 |
| Suffering something picked up from boulangerie? |
The Telegraph Toughie |
02 Jul 2021 |
| Aleve may relieve it |
Premier Sunday |
02 May 2021 |
| Bodily suffering |
The Times Concise |
09 Apr 2021 |
| Ache |
Eugene Sheffer |
08 Apr 2021 |
| Major inconvenience |
Newsday |
21 Mar 2021 |
| Aspirin target |
Thomas Joseph |
08 Feb 2021 |
| Wong To Yick target |
USA Today |
06 Feb 2021 |
| Icy Hot target |
Universal |
23 Jan 2021 |
| ___ in the neck |
Universal |
02 Jan 2021 |
| Aspirin target |
Newsday |
28 Dec 2020 |
| Salonpas target |
USA Today |
09 Dec 2020 |
| Agony |
USA Today |
27 Nov 2020 |
| Grimace cause |
Wall Street Journal |
24 Nov 2020 |
| Hassle |
USA Today |
22 Nov 2020 |
| Total inconvenience |
New York Times |
13 Nov 2020 |
| One's caught by hammer -- agony! |
The Telegraph Cryptic |
03 Nov 2020 |
| Agony |
The Sun Two Speed |
31 Oct 2020 |
| French bread causing anguish |
The Sun Two Speed |
31 Oct 2020 |
| Pill ... or a reason to take a pill |
New York Times |
15 Sep 2020 |
| Counterpart of pleasure |
USA Today |
08 Sep 2020 |
| Concealed by EPA interested in sign of something distressing |
Irish Times Crosaire |
01 Aug 2020 |
| Analgesic target |
Wall Street Journal |
13 Jun 2020 |
| Bother |
New York Times |
09 Jun 2020 |
| Annoyance |
USA Today |
21 May 2020 |
| Royal problem? |
The Washington Post |
17 May 2020 |
| Royal problem? |
LA Times Daily |
17 May 2020 |
| Nuisance |
Newsday |
30 Apr 2020 |
| Masochist's pleasure |
New York Times |
05 Apr 2020 |
| "No __, no gain" |
LA Times Daily |
16 Mar 2020 |
| 'No __, no gain' |
The Washington Post |
16 Mar 2020 |
| Nuisance |
USA Today |
10 Mar 2020 |
| It's often evaluated on a :) to :( scale |
Universal |
26 Feb 2020 |
| Aspirin's target |
USA Today |
26 Feb 2020 |
| Pest |
USA Today |
20 Feb 2020 |
| Characters in EPA interested in result of the injury |
Irish Times Crosaire |
14 Dec 2019 |
| With 71-Across, Bengay's purpose ... or this puzzle's theme |
Universal |
28 Nov 2019 |
| Ibuprofen target |
USA Today |
26 Oct 2019 |
| Suffering or distress |
The Times Concise |
24 Oct 2019 |
| It might make you smart |
Wall Street Journal |
15 Oct 2019 |
| __ in the neck (pest) |
Newsday |
09 Oct 2019 |
| Ache |
The Washington Post |
02 Sep 2019 |
| Ache |
LA Times Daily |
02 Sep 2019 |
| 'No ___, no gain' |
USA Today |
04 Aug 2019 |
| Tylenol target |
New York Times |
08 Jul 2019 |
| Distress |
Canadiana |
13 May 2019 |
| Ache |
Premier Sunday |
12 May 2019 |
| Tylenol target |
LA Times Daily |
23 Apr 2019 |
| Tylenol target |
The Washington Post |
23 Apr 2019 |
| "No ___, no gain" (gym saying) |
Family Time |
14 Apr 2019 |
| __ in the neck (annoyance) |
Newsday |
21 Jan 2019 |
| "No ___, no gain!" |
Universal |
10 Jan 2019 |
| Major nuisance |
Newsday |
06 Jan 2019 |
| Characters raised in California put out by nuisance |
Irish Times Crosaire |
05 Jan 2019 |
| Tylenol target |
|
|
| "No ___, no gain" |
|
|
| It might make you smart |
|
|
| Tylenol target |
|
|
| Ibuprofen target |
|
|
| Item crammed into a kitchen cabinet |
|
|
| "No ___, no gain!" |
|
|
| Ache |
|
|
| Icy Hot target |
Wall Street Journal |
10 Dec 2018 |
| French bread causing tummy ache? |
The Telegraph Cryptic |
13 Nov 2018 |
| No gain? No this |
Universal |
05 Oct 2018 |
| Tylenol target |
Wall Street Journal |
03 Oct 2018 |
| Considerable inconvenience |
Newsday |
18 Aug 2018 |
| Irksome sort |
USA Today |
16 Jul 2018 |
| Pest |
The Chronicle of Higher Education |
11 May 2018 |
| Royal annoyance? |
LA Times Daily |
04 May 2018 |
| Royal annoyance? |
The Washington Post |
04 May 2018 |
| Dad at home, someone hard to deal with? |
The Telegraph Cryptic |
02 Mar 2018 |
| Agony |
The Telegraph Quick |
21 Feb 2018 |
| More than discomfort |
Universal |
05 Feb 2018 |
| Tough person to tolerate |
New York Times |
01 Feb 2018 |
| Annoying sort |
USA Today |
29 Jan 2018 |
| Patient quality that may be measured by a facial analogue scale |
The Washington Post Sunday |
21 Jan 2018 |
| "No ___, no gain" |
USA Today |
20 Jan 2018 |
| Cause of some grimacing |
Wall Street Journal |
02 Jan 2018 |
| Pest |
|
|
| Icy Hot target |
|
|
| Royal annoyance? |
|
|
| Tylenol target |
|
|
| Irksome sort |
|
|
| No gain? No this |
|
|
| More than discomfort |
|
|
| Tough person to tolerate |
|
|
| Annoying sort |
|
|
| Major annoyance |
Newsday |
26 Nov 2017 |
| Charley horse consequence |
USA Today |
24 Nov 2017 |
| Criticise involving one showing discomfort |
The Telegraph Toughie |
11 Oct 2017 |
| Big nuisance |
New York Times |
26 Sep 2017 |
| Nuisance |
New York Times |
04 Aug 2017 |
| Annoying person |
The Times Concise |
06 Jul 2017 |
| What nociceptors sense |
Wall Street Journal |
20 Apr 2017 |
| Annoyance, so to speak |
Newsday |
22 Feb 2017 |
| Nuisance |
|
|
| Big nuisance |
|
|
| Charley horse consequence |
|
|
| Annoying inconvenience |
Newsday |
29 Dec 2016 |
| Hurt |
LA Times Daily |
21 Dec 2016 |
| Aleve target |
USA Today |
09 Dec 2016 |
| Advil target |
USA Today |
10 Nov 2016 |
| Aspirin target |
LA Times Daily |
03 Nov 2016 |
| A ___in the neck |
Canadiana |
12 Sep 2016 |
| Pesky kid |
USA Today |
25 Jul 2016 |
| "Royal" nuisance |
USA Today |
23 Jul 2016 |
| Aleve target |
Premier Sunday |
26 Jun 2016 |
| Big hassle |
Newsday |
23 Jun 2016 |
| What acupuncture relieves, for some |
LA Times Daily |
15 Jun 2016 |
| It hurts |
USA Today |
14 May 2016 |
| Nuisance |
Jonesin |
23 Feb 2016 |
| Result when one's smashed in face |
The Times Cryptic |
21 Jan 2016 |
| It hurts |
|
|
| "Royal" nuisance |
|
|
| Hurt |
|
|
| What acupuncture relieves, for some |
|
|
| Pesky kid |
|
|
| Advil target |
|
|
| Suffering |
New York Times |
29 Dec 2015 |
| Protected areas in Nepal leads to torment |
Irish Times Crosaire |
08 Oct 2015 |
| Sleep is interrupted by one returning: a nuisance |
The Telegraph Toughie |
29 Sep 2015 |
| Unpleasant feeling from French bread |
The Telegraph Cryptic |
22 Sep 2015 |
| Analgesic target |
Eugene Sheffer |
04 Aug 2015 |
| Ache |
The Telegraph Quick |
03 Aug 2015 |
| Produce pictures mainly showing suffering |
The Telegraph Cryptic |
26 Jul 2015 |
| Reliever's target |
Wall Street Journal |
13 Jul 2015 |
| Prerequisite for gain? |
Universal |
02 Jul 2015 |
| Bothersome task |
Newsday |
25 Jun 2015 |
| Cause of grimacing |
USA Today |
07 Jun 2015 |
| Annoyance |
Newsday |
19 Apr 2015 |
| Royal __ |
Newsday |
28 Mar 2015 |
| Anguish |
The Guardian Quick |
14 Feb 2015 |
| Advil target |
Universal |
02 Feb 2015 |
| Bothersome task |
|
|
| Royal __ |
|
|
| __ in the neck (pest) |
|
|
| Advil target |
|
|
| Suffering |
|
|
| Cause of grimacing |
|
|
| French bread |
|
|
| Thorn in one's side |
|
|
| Prerequisite for gain? |
|
|
| Agony |
|
|
| Bothersome person |
|
|
| Hassle |
|
|
| Pest |
|
|
| What an analgesic treats |
|
|
| Pesky one |
|
|
| Major inconvenience |
|
|
| Proverbial problem for the neck or butt |
|
|
| Big bother |
|
|
| "No ___, no gain" |
|
|
| Bodily distress |
|
|
| It hurts |
|
|
| Physical suffering |
|
|
| Annoyance |
|
|
| Ouch inducer |
|
|
| What a dolorimeter measures |
|
|
| Ibuprofen target |
|
|
| Distress |
|
|
| Ache |
|
|
| "I feel your __" |
|
|
| Advil target |
|
|
| Little brother, at times |
|
|
| Ibuprofen target |
|
|
| Unpleasant sensation |
|
|
| Suffering's partner, in court |
|
|
| Nuisance, so to speak |
|
|
| "I feel your __" |
|
|
| Prerequisite for gain? |
|
|
| Hurt |
|
|
| Hurt |
|
|
| Suffering partner? |
|
|
| Reason to take acetaminophen |
|
|
| Tylenol target |
|
|
| Young brother, often |
|
|
| Hassle |
|
|
| Aspirin target |
|
|
| Arduous chore |
|
|
| Reason for a clinic visit |
|
|
| Sibling, at times? |
|
|
| It may be unbearable |
|
|
| Aspirin target |
|
|
| Major hassle |
|
|
| Nuisance |
|
|
| Hassle |
|
|
| See 1-Across |
|
|
| Annoyance |
|
|
| "No ___, no gain" (gym saying) |
|
|
| Royal annoyance |
|
|
| Suffering partner? |
|
|
| Vexation |
|
|
| Analgesic target |
|
|
| See 1-Across |
|
|
| Aspirin target |
|
|
| Analgesic's target |
|
|
| Aspirin target |
|
|
| Major nuisance |
|
|
| "Royal" annoyance |
|
|
| French bread |
|
|
| T-___ (noted Auto-Tune user) |
|
|
| What lines with stars at the end indicate in comics |
|
|
| "No __, no gain" |
|
|
| Suffering's partner, in court |
|
|
| Requisite for gain, so they say |
|
|
| Partner of suffering |
|
|
| "No __, no gain" |
|
|
| "Royal" annoyance |
|
|
| Big bother |
|
|
| Some athletes play through it |
|
|
| "Royal" nuisance |
|
|
| Analgesic's target |
|
|
| Bother |
|
|
| Aspirin target |
|
|
| Analgesic target |
|
|
| Tylenol target |
|
|
| It can be chronic or shooting |
|
|
| Hurt |
|
|
| Analgesic's target |
|
|
| "Royal" nuisance |
|
|
| Aspirin target |
|
|
| It can be chronic or shooting |
|
|
| That hurts |
|
|
| Clubber Lang's prediction for Rocky |
|
|
| Analgesic's target |
|
|
| Tylenol target |
|
|
| Cause of a wince |
|
|
| Emotional distress |
|
|
| Gain prerequisite |
|
|
| Cause of a wince |
|
|
| It might be in the neck |
|
|
| Grimace inducer |
|
|
| Nuisance |
|
|
| "___ forces even the innocent to lie": Publilius Syrus |
|
|
| Charley horse, e.g. |
|
|
| Suffering partner |
|
|
| Analgesic target |
|
|
| Bratty kid |
|
|
| __ in the neck (annoyance) |
|
|
| Tylenol target |
|
|
| Stitch, e.g. |
|
|
| It "clings cruelly to us," according to Keats |
|
|
| Botheration |
|
|
| "No ___, no gain" |
|
|
| Bothersome person |
|
|
| Pesky kid, e.g. |
|
|
| Pest |
|
|
| Partner of suffering |
|
|
| Anguish |
|
|
| Anguish |
|
|
| Partner of suffering |
|
|
| Pest |
|
|
| Result of punishment |
|
|
| Pill |
|
|
| Baby brother, often |
|
|
| Suffering partner |
|
|
| No gain without it |
|
|
| Prerequisite for a weightlifter's gain? |
|
|
| Aleve target |
|
|
| Hassle |
|
|
| Feeling that makes you say "Ow!" |
|
|
| Pesky sort |
|
|
| Aleve target |
|
|
| Nuisance |
|
|
| Number's target? |
|
|
| Pesky kid |
|
|
| "No ___, no gain" |
|
|
| Reason to take butorphanol |
|
|
| No gain without it |
|
|
| Annoying sort |
|
|
| Partner of suffering |
|
|
| Agony |
|
|
| French bread |
|
|
| Endorphins producer |
|
|
| Major nuisance |
|
|
| Advil target |
|
|
| Bother |
|
|
| Tylenol's target |
|
|
| Cause to grimace |
|
|
| Grief |
|
|
| Percocet's target |
|
|
| Distress |
|
|
| Arduous chore |
|
|
| It can follow a fall |
|
|
| What an analgesic stops |
|
|
| Distress |
|
|
| Annoying one |
|
|
| Nuisance |
|
|
| Irksome sort |
|
|
| Annoying person |
|
|
| Nuisance |
|
|
| Ache |
|
|
| Pesky one |
|
|
| Neuralgia |
|
|
| "No ___, no gain" |
|
|
| Ouch inducer |
|
|
| Pesky kid |
|
|
| Hardly pleasure |
|
|
| Suffering partner? |
|
|
| Discomfort |
|
|
| Annoyance |
|
|
| Neck ailment? |
|
|
| Post-marathon sensation, perhaps |
|
|
| Annoyance |
|
|
| Pestiferous person |
|
|
| Reason to take acetaminophen |
|
|
| Clinton felt yours |
|
|
| Soreness |
|
|
| Torment |
|
|
| Analgesic target |
|
|
| Distress |
|
|
| Pesky kid |
|
|
| Pesky sort |
|
|
| Stitch, sometimes |
|
|
| Cause distress |
|
|
| Nudnik |
|
|
| Clinton feels yours |
|
|
| Hurt |
|
|
| "No __, no gain" |
|
|
| Hassle |
|
|
| No ___ no gain! |
|
|
| Tedious type |
|
|
| Major nuisance |
|
|
| Grief |
|
|
| French bread |
|
|
| Gain prerequisite |
|
|
| Hurt |
|
|
| Aspirin's target |
|
|
| "King of ___" ('83 hit for the Police) |
|
|
| Gain prerequisite? |
|
|
| Tylenol's target |
|
|
| No ____, no gain |
|
|
| Annoyance |
|
|
| Nuisance |
|
|
| Bread in Brest |
|
|
| Cause to grimace |
|
|
| Annoyance |
|
|
| Excedrin target |
|
|
| Ache |
|
|
| Bother |
|
|
| Nice bread |
|
|
| Aggrieve |
|
|
| Ache's cousin |
|
|
| "No ___, no gain" |
|
|
| Physical suffering |
|
|
| Anodyne's target |
|
|
| Stitch, e.g. |
|
|
| Discomfort |
|
|
| French bread |
|
|
| Gagne ___ (French breadwinner) |
|
|
| Bread, in Brest |
|
|
| Anguish |
|
|
| Troublesome one |
|
|
| This may stab or shoot |
|
|
| Ache |
|
|
| Travail |
|
|
| Botheration |
|
|
| Stitch |
|
|
| Neck affliction |
|
|
| "Our Lady of ___": Swinburne |
|
|
| Joy's antithesis |
|
|
| What a French baker produces |
|
|
| ___ in the neck |
|
|
| Ouch's cause |
|
|
| Strong discomfort |
|
|
| "Sweet is pleasure after ___": Dryden |
|
|
| What dols measure |
|
|
| Misery |
|
|
| Provoke |
|
|
| Bread, in Bayonne |
|
|
| Agony |
|
|
| Ache. |
|
|
| French bread. |
|
|
| Sometime neck ailment. |
|
|
| Distress. |
|
|
| Trouble. |
|
|
| Anguish. |
|
|
| Bread, in France. |
|
|
| Cause to suffer. |
|
|
| Bread: Fr. |
|
|
| Bread: French. |
|
|
| Charley horse symptom. |
|
|
| Neck ailment. |
|
|
| Afflict. |
|
|
| Neck symptom. |
|
|
| Unhappy reaction. |
|
|
| Misery. |
|
|
| Neck affliction. |
|
|
| Disquiet. |
|
|
| Render uneasy. |
|
|
| Suffering. |
|
|
| Twinge. |
|
|
| Annoyance |
|
|
| Obnoxious brat |
|
|
| World of hurt |
|
|