Highly significant Crossword Clue

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Here is the answer for the crossword clue Highly significant last seen in Newsday puzzle. We have found 40 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 5 letters. We think the likely answer to this clue is MAJOR.

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Crossword Answer For Highly significant:

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4 Potential Answers:

AnswerLengthSourceDate
MAJOR Highly significant (5) Newsday Aug 28, 2022
EPOCHAL Highly significant (7) Newsday Dec 4, 2020
GREAT Highly significant (5)
HISTORIC Highly significant (8)

36 Similar Clues:

RankAnswerLengthSourceDate
32% QUANTUMLEAP Sudden highly significant advance (11)
4% IMPORT Significance (6) LA Times Daily Oct 3, 2025
4% NOTABLE Significant (7) USA Today Sep 6, 2025
3% REDLETTERDAY Happy and significant occasion (3-6,3) (12) The Guardian Quick Oct 7, 2025
3% NOTEWORTHY Interesting or significant (10) (10) Mirror Classic Oct 3, 2025
3% SHARPCORNER Highly critical grain producer? (11) LA Times Daily Oct 2, 2025
3% VIRULENT Highly infectious (8) The Telegraph Quick Sep 28, 2025
3% MINUTEST Least significant flash on street (8) The Telegraph Cryptic Sep 25, 2025
3% ADEPT Highly skilled (5) Commuter Sep 23, 2025
3% FOURSTAR Highly-rated, as a film (8) Eugene Sheffer Sep 23, 2025

Last appeared together with the following clues in Newsday puzzle

Highly significant Crossword Clue
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We found 40 solutions for Highly significant. The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is MAJOR.

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