Most significant Crossword Clue

Here is the answer for the crossword clue Most significant last seen in Newsday puzzle. We have found 40 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 4 letters. We think the likely answer to this clue is MAIN.

Crossword Answer For Most significant:

40 Potential Answers:

Rank	Answer	Length	Source	Date
98%	MAIN Most significant	(4)	Newsday	May 18, 2025
32%	MAINCLAIMTOFAME Most significant entitlement	(15)
28%	THEBIGGAME Most significant sporting event	(10)	Universal	Jan 19, 2024
25%	MAINTAIN Isn't involved in the most significant claim	(8)
23%	MAINE COON Most significant time to receive care of cat	(10)	The Times Cryptic	Sep 26, 2022
23%	TOPIC Most significant sources of inspiration clearly matter	(5)
21%	STICKMAN Criticism most significant, dismissing one crude drawing	(8)	The Guardian Cryptic	Apr 18, 2023
21%	NOISINESS Character attracted to most significant of crimes, antisocial behaviour?	(9)
21%	DEEPEST One side of capital city on river, most significant	(7)	The Telegraph Toughie	Oct 20, 2020
18%	WARDROBE In children's fiction, Professor Digory Kirke's most significant piece of furniture	(8)	The Times Specialist Sunday	Jun 25, 2023

Show More Answers (30)

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Your Crossword Clues FAQ Guide

What is the answer of Most significant Crossword Clue?

In a crossword puzzle, "Most significant" can be represented by the word "MAIN." Think of it as the primary or central element that stands out among the rest. It's a concise way to convey importance or prominence in a puzzle-solving context.