The substance does make a difference (6) Crossword Clue

Here is the answer for the crossword clue The substance does make a difference (6) . We have found 40 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 6 letters. We think the likely answer to this clue is MATTER.

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Crossword Answer For The substance does make a difference (6):

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40 Potential Answers:

RankAnswerLengthSourceDate
98% MATTER The substance does make a difference (6) (6)
8% IDGOEITHERWAY "Makes no difference to me" (13) New York Times Feb 16, 2026
8% DOES "What difference __ it make?" (4) LA Times Daily Feb 1, 2026
7% LYES Soapmaking substances (4) Universal May 20, 2026
7% THAT "__ does it!" (4) Commuter May 18, 2026
7% OTHER Different (5) Thomas Joseph May 15, 2026
7% GOOS Sticky substances (4) Newsday May 12, 2026
7% OTRO Different, to Diego (4) Wall Street Journal May 12, 2026
7% GEL Hairstyling substance (3) Puzzler Backwords May 11, 2026
7% TUNE Singing a different ___ (4) USA Today May 10, 2026
The substance does make a difference (6) Crossword Clue
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We found 40 solutions for The substance does make a difference (6). The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is MATTER.

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