What makes up a significant proportion of the universe is distressing subject (4,6) Crossword Clue

Here is the answer for the crossword clue What makes up a significant proportion of the universe is distressing subject (4,6) last seen in Guardian Quick Cryptic puzzle. We have found 40 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 10 letters. We think the likely answer to this clue is DARKMATTER.

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Crossword Answer For What makes up a significant proportion of the universe is distressing subject (4,6):

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40 Potential Answers:

RankAnswerLengthSourceDate
98% DARKMATTER What makes up a significant proportion of the universe is distressing subject (4,6) (10) The Guardian Quick Cryptic Oct 4, 2025
5% ATONES Makes up (for) (6) New York Times Jun 1, 2026
5% ADLIB Make up on the spot (5) LA Times Daily May 28, 2026
5% CRUCIAL Vital, significant (7) (7) Puzzler May 28, 2026
5% TOPIC Subject (5) Wall Street Journal May 26, 2026
5% ISNT "This ___ what I signed up for!" (4)
5% ERAS Significant periods (4) USA Today May 22, 2026
5% ADD Make sense, with "up" (3) New York Times May 21, 2026
5% SLAP Returned mate's make-up (4) The Times Quick Cryptic May 19, 2026
5% ESTATE Subject of a will (6) Thomas Joseph May 18, 2026

Last appeared together with the following clues in Guardian Quick Cryptic puzzle

What makes up a significant proportion of the universe is distressing subject (4,6) Crossword Clue
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We found 40 solutions for What makes up a significant proportion of the universe is distressing subject (4,6). The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is DARKMATTER.

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