"What's up __ that?" Crossword Clue

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Here is the answer for the crossword clue 'What's up ___ that?' last seen in USA Today puzzle. We have found 41 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 4 letters. We think the likely answer to this clue is WITH.

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Crossword Answer For 'What's up ___ that?':

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41 Potential Answers:

RankAnswerLengthSourceDate
98% WITH 'What's up ___ that?' (4) USA Today Nov 13, 2022
95% DOC "What's up, __?" (3) Commuter Dec 30, 2025
95% SKY What's up? (3) Universal Dec 9, 2025
90% PASA "Qué --?" (Spanish for "What's up?") (4) Premier Sunday Jan 25, 2026
85% ELOPE What Anora and Vanya do in 2024's "Anora" (5) New York Times Jan 17, 2026
85% PATIENCE What's needed to endure comic opera by G&S (8) The Times Quick Cryptic Jan 15, 2026
85% HEYMAN "What's up, bro!" (6) The Atlantic Nov 19, 2025
80% SOON "S" in ASAP (4)
80% VPS No. 2's (3) New York Times Feb 1, 2026
80% EEK "What was that?!" (3) The Atlantic Jan 29, 2026

Last appeared together with the following clues in USA Today puzzle

"What's up __ that?" Crossword Clue
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We found 41 solutions for 'What's up ___ that?'. The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is WITH.

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