"What's up __ that?" Crossword Clue

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Here is the answer for the crossword clue 'What's up ___ that?' last seen in USA Today puzzle. We have found 41 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 4 letters. We think the likely answer to this clue is WITH.

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Crossword Answer For 'What's up ___ that?':

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41 Potential Answers:

RankAnswerLengthSourceDate
98% WITH 'What's up ___ that?' (4) USA Today Nov 13, 2022
95% SKY What's up? (3) Wall Street Journal Oct 13, 2025
95% DOC "What's up, ___?" (3) New York Times Oct 5, 2025
90% SECURE What the "S" of HTTPS stands for (6) USA Today Oct 13, 2025
90% HEY "What's up" (3) Universal Aug 9, 2025
85% AMESS "What ___!" ("Clean up this room!") (5) LA Times Mini Oct 4, 2025
81% NAMES What bylines are made up of (5) USA Today Aug 19, 2025
81% OKAY What a thumbs up means (4)
76% MIN What sixty seconds add up to, for short (3)
76% SIERRA S on the radio? (6) The Telegraph Cross Atlantic Oct 20, 2025

Last appeared together with the following clues in USA Today puzzle

"What's up __ that?" Crossword Clue
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We found 41 solutions for 'What's up ___ that?'. The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is WITH.

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