"What's up with ___?" Crossword Clue

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Here is the answer for the crossword clue "What's up with ___?" last seen in Universal puzzle. We have found 41 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 4 letters. We think the likely answer to this clue is THAT.

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Crossword Answer For "What's up with ___?":

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41 Potential Answers:

RankAnswerLengthSourceDate
98% THAT "What's up with ___?" (4) Universal Feb 12, 2023
90% DOC "What's up, __?" (3) Commuter Dec 30, 2025
90% SKY What's up? (3) Universal Dec 9, 2025
82% HEYMAN "What's up, bro!" (6) The Atlantic Nov 19, 2025
77% TRYING Tiresome, what judges get up to (6) The Times Cryptic Dec 30, 2025
77% TON What a pickup might pick up? (3)
77% DUST What a microfiber mitt picks up (4) USA Today Dec 19, 2025
77% ESS S (3) The Telegraph Cross Atlantic Dec 18, 2025
77% SECURE What the "S" of HTTPS stands for (6) USA Today Oct 13, 2025
73% NAME "What's in a __?" (4) Commuter Jan 3, 2026

Last appeared together with the following clues in Universal puzzle

"What's up with ___?" Crossword Clue
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We found 41 solutions for "What's up with ___?". The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is THAT.

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With our crossword solver search engine you have access to over 7 million clues. You can narrow down the possible answers by specifying the number of letters it contains. We found more than 41 answers for "What's up with ___?".