"What's up with ___?" Crossword Clue

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Here is the answer for the crossword clue "What's up with ___?" last seen in Universal puzzle. We have found 41 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 4 letters. We think the likely answer to this clue is THAT.

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Crossword Answer For "What's up with ___?":

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41 Potential Answers:

RankAnswerLengthSourceDate
98% THAT "What's up with ___?" (4) Universal Feb 12, 2023
95% HEY "What's up" (3) Universal Aug 9, 2025
85% NAMES What bylines are made up of (5) USA Today Aug 19, 2025
85% OKAY What a thumbs up means (4)
85% DOC "What's up, __?" (3) Commuter Jun 12, 2025
81% NOICE What "straight up" means at a bar (5) Premier Sunday Aug 17, 2025
81% REVEILLE This is what soldiers might get up to (8) The Times Quick Cryptic Aug 4, 2025
81% TENT What's up with some weddings (4) Newsday Jul 26, 2025
81% REESE "_'s Puffs, _'s Puffs / Eat 'em up, eat 'em up, eat 'em up" (5)
81% TAILS Heads on the floor? What's up? (5)

Last appeared together with the following clues in Universal puzzle

"What's up with ___?" Crossword Clue
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We found 41 solutions for "What's up with ___?". The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is THAT.

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With our crossword solver search engine you have access to over 7 million clues. You can narrow down the possible answers by specifying the number of letters it contains. We found more than 41 answers for "What's up with ___?".