"What's up with ___?" Crossword Clue

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Here is the answer for the crossword clue "What's up with ___?" last seen in Universal puzzle. We have found 41 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 4 letters. We think the likely answer to this clue is THAT.

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Crossword Answer For "What's up with ___?":

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41 Potential Answers:

RankAnswerLengthSourceDate
98% THAT "What's up with ___?" (4) Universal Feb 12, 2023
90% SKY What's up? (3) Wall Street Journal Oct 13, 2025
90% DOC "What's up, ___?" (3) New York Times Oct 5, 2025
86% SECURE What the "S" of HTTPS stands for (6) USA Today Oct 13, 2025
86% HEY "What's up" (3) Universal Aug 9, 2025
82% AMESS "What ___!" ("Clean up this room!") (5) LA Times Mini Oct 4, 2025
77% NAMES What bylines are made up of (5) USA Today Aug 19, 2025
77% OKAY What a thumbs up means (4)
73% SYSTEM "S" in GPS (6)
73% ELSE "What __ is there?" (4) LA Times Daily Oct 16, 2025

Last appeared together with the following clues in Universal puzzle

"What's up with ___?" Crossword Clue
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We found 41 solutions for "What's up with ___?". The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is THAT.

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With our crossword solver search engine you have access to over 7 million clues. You can narrow down the possible answers by specifying the number of letters it contains. We found more than 41 answers for "What's up with ___?".