"What's up with ___?" Crossword Clue

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Here is the answer for the crossword clue "What's up with ___?" last seen in Universal puzzle. We have found 41 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 4 letters. We think the likely answer to this clue is THAT.

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Crossword Answer For "What's up with ___?":

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41 Potential Answers:

RankAnswerLengthSourceDate
98% THAT "What's up with ___?" (4) Universal Feb 12, 2023
95% NORTH What's up? (5) Universal May 13, 2026
85% SYS What the S in iOS stands for: abbr. (3) The Atlantic Jun 1, 2026
85% ISNT "This ___ what I signed up for!" (4)
81% ESS S (3) The Telegraph Cross Atlantic Jun 1, 2026
81% OHO "I see what you're up to!" (3) The Atlantic May 3, 2026
81% HIALL "What's up, everyone!" (5) USA Today Mar 22, 2026
81% HOWRU Texter's "What's up?" (5) LA Times Mini Mar 4, 2026
76% HEEL What helps you get a leg up? (4) New York Times Jun 2, 2026
76% SIL The "S" in RSVP (3) Commuter May 30, 2026

Last appeared together with the following clues in Universal puzzle

"What's up with ___?" Crossword Clue
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We found 41 solutions for "What's up with ___?". The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is THAT.

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With our crossword solver search engine you have access to over 7 million clues. You can narrow down the possible answers by specifying the number of letters it contains. We found more than 41 answers for "What's up with ___?".