____Pen, it's needed for a reaction Crossword Clue

Here is the answer for the crossword clue ____Pen, it's needed for a reaction last seen in Telegraph Cross Atlantic puzzle. We have found 40 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 3 letters. We think the likely answer to this clue is EPI.

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Crossword Answer For ____Pen, it's needed for a reaction:

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40 Potential Answers:

RankAnswerLengthSourceDate
98% EPI ____Pen, it's needed for a reaction (3) The Telegraph Cross Atlantic Mar 21, 2025
58% WINCE Pained reaction (5) Wall Street Journal Dec 29, 2025
58% ITCH Rash reaction? (4)
58% OOHS Awed reactions (4) New York Times Dec 19, 2025
58% RASH Skin reaction (4) Commuter Dec 16, 2025
55% OOF Gut-punch reaction (3) Eugene Sheffer Jan 5, 2026
55% NET "Nothing but ___!" (reaction to a swish) (3) New York Times Dec 30, 2025
55% TABLEFLIP Extreme reaction to frustration (9) Wall Street Journal Dec 29, 2025
55% TONSOFFUN Eliciting a "Yippee!" reaction (9) Universal Dec 29, 2025
55% GROAN Bad pun reaction (5) Universal Dec 25, 2025

Last appeared together with the following clues in Telegraph Cross Atlantic puzzle

____Pen, it's needed for a reaction Crossword Clue
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We found 40 solutions for ____Pen, it's needed for a reaction. The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is EPI.

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