Mainframe "brain," briefly Crossword Clue

Here is the answer for the crossword clue Mainframe 'brain,' briefly . We have found 40 possible answers for this clue in our database. Among them, one solution stands out with a 98% match which has a length of 3 letters. We think the likely answer to this clue is CPU.

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Crossword Answer For Mainframe 'brain,' briefly:

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40 Potential Answers:

RankAnswerLengthSourceDate
98% CPU Mainframe 'brain,' briefly (3)
7% CPUS Mainframe brains (4)
6% MENTAL Brain-based (6) Newsday Jan 7, 2026
6% LOAF Brains (4) The Telegraph Cross Atlantic Dec 28, 2025
6% LOBES Brain sections (5) New York Times Mini Dec 23, 2025
6% MRI Brain scan (3) TV Dec 21, 2025
6% STEM Brain __ (4) LA Times Daily Dec 11, 2025
5% SPEC Detail, briefly (4) Eugene Sheffer Jan 19, 2026
5% PSA "This Is your brain on drugs," e.g., for short (3) New York Times Jan 18, 2026
5% MAGS Periodicals, briefly (4) LA Times Daily Jan 15, 2026
Mainframe "brain," briefly Crossword Clue
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We found 40 solutions for Mainframe 'brain,' briefly. The top solutions are determined by popularity, ratings and frequency of searches. The most likely answer for the clue is CPU.

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With our crossword solver search engine you have access to over 7 million clues. You can narrow down the possible answers by specifying the number of letters it contains. We found more than 40 answers for Mainframe 'brain,' briefly.